Chronic Pain Behaviours in Mice

Item

Title
Chronic Pain Behaviours in Mice
Source
ZOOL 567, Fall 2021
Contributor
Pixabay, Prezi, PxHere, Wikimedia Commons
Creator
Pigott, Taylor
Description
This project focusses on a major development in the study of chronic pain in mice – the transition from studying reflexive pain behaviours to voluntary pain behaviours. Historic pain research in mice focussed on reflexive responses to uncomfortable stimuli. Many researchers have begun to develop behavioural tests that assess voluntary behaviours that are more likely to represent the experience of chronic pain.
References
Cobos, E. J., Ghasemlou, N., Araldi, D., Segal, D., Duong, K., & Woolf, C. J. (2012). Inflammation-induced decrease in voluntary wheel running in mice: A nonreflexive test for evaluating inflammatory pain and analgesia. Pain, 153(4), 876–884. https://doi.org/10.1016/j.pain.2012.01.016
Guo, W., Zou, S., Mohammad, Z., Wang, S., Yang, J., Li, H., Dubner, R., Wei, F., Chung, M. K., Ro, J. Y., & Ren, K. (2019). Voluntary biting behavior as a functional measure of orofacial pain in mice. Physiology and Behavior, 204(December 2018), 129–139. https://doi.org/10.1016/j.physbeh.2019.02.024
Kurejova, M., Nattenmüller, U., Hildebrandt, U., Selvaraj, D., Stösser, S., & Kuner, R. (2010). An improved behavioural assay demonstrates that ultrasound vocalizations constitute a reliable indicator of chronic cancer pain and neuropathic pain. Molecular Pain, 6, 1–7. https://doi.org/10.1186/1744-8069-6-18
Lister, K. C., Bouchard, S. M., Markova, T., Aternali, A., Denecli, P., Pimentel, S. D., Majeed, M., Austin, J. S., Amanda, A. C., & Mogil, J. S. (2020). Chronic pain produces hypervigilance to predator odor in mice. Current Biology, 30(15), R866–R867. https://doi.org/10.1016/j.cub.2020.06.025
Millecamps, M., Shi, X. Q., Piltonen, M., Echeverry, S., Diatchenko, L., Zhang, J., & Stone, L. S. (2020). The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain. Neurobiology of Aging, 89, 1–11. https://doi.org/10.1016/j.neurobiolaging.2019.12.018
Mogil, J. S. (2009). Animal models of pain: Progress and challenges. Nature Reviews Neuroscience, 10(4), 283–294. https://doi.org/10.1038/nrn2606
Mogil, J. S., Graham, A. C., Ritchie, J., Hughes, S. F., Austin, J. S., Schorscher-Petcu, A., Langford, D. J., & Bennett, G. J. (2010). Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice. Molecular Pain, 6, 1–15. https://doi.org/10.1186/1744-8069-6-34.
Pitzer, C., Kuner, R., & Tappe-Theodor, A. (2016). Voluntary and evoked behavioral correlates in neuropathic pain states under different social housing conditions. Molecular Pain, 12, 1–15. https://doi.org/10.1177/1744806916656635
Shepherd, A. J., & Mohapatra, D. P. (2018). Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice. Neuropharmacology, 130, 18–29. https://doi.org/10.1016/j.neuropharm.2017.11.036
Date
12/01/2021
Category
Learning, Memory, & Cognition
Item sets
Topic Dissemination Items